Moreover, blocking glutamate receptor function with memantine in Nf1flox/flox; hGFAP-Cre mice following ON-CR at 6 weeks of age (Fig. 6c) results in reduced tumor proliferation (%Ki67+ cells; Fig. 6d), as well as reduced expression of optic nerve Il1β (Fig. 6e) and Ccl5 (Fig. 6f). This evidence concerns the gene HGFAC and neoplasm.