Likewise, skin injury also accelerates the development and growth of cutaneous neurofibromas in Nf1-mutant mice, associated with increased Ccl2 and Ccl5 expression [48], while partial sciatic nerve transection induces the formation of neurofibromas in Nf1-mutant mice at the site of the injury [49]. The gene discussed is NF1; the disease is plexiform neurofibroma.