In this study, we determined the impact of maternal obesity on the brain plasticity in adult offspring, with a particular focus on EphA4/ephrinA3-signaling, astroglia and microglia reactions and factors that may affect the vasculature, including gap junction protein connexin 43 (Cx43), vessel coverage of astrocytic end-feet (aquaporin-4, AQP4). This evidence concerns the gene EPHA4 and obesity due to melanocortin 4 receptor deficiency.