On the other hand, CD163 M2-macrophages are a subset of naive M0-macrophage cells that induce the apoptosis of CD8 via the PD-L1 expression; prevent the CD8 T-cells from migrating to the tumor site; and facilitate the tumor progression, metastatis, and angiogenesis via the secretion of the TGF-β, MMP-2, IL-10, and IL-13 [36, 37]. The gene discussed is MMP2; the disease is neoplasm.