For instance, the perturbation of an enhancer element upstream of PHF19 (Fig. 6E) that overlaps SNPs in the 95% credible set for a rheumatoid arthritis GWAS signal [71] resulted in immune-related DEGs not reported in K562 cells [49], including TRAF1 (Fig. 6F). Here, TRAF1 is linked to rheumatoid arthritis.