For example, when perturbing the enhancer linked to GIGYF1, which overlaps SNPs in the 95% credible set for a type 2 diabetes (T2D) GWAS signal (Fig. 6A) [69], we found that GIGYF1 was significantly differentially expressed (FDR = 5.14e−14), with perturbed cells showing approximately a 10% reduction in expression (Fig. 6B). The gene discussed is GIGYF1; the disease is type 2 diabetes mellitus.