CRP and COVID-19: The variables of age, gender, number of comorbidities, respiratory rate, SpO2, state of consciousness, urea nitrogen, and C Reactive protein were included in the score; obtaining a scale of 0 to 21 points and a performance of 0.79 (95% CI: 0.78–0.79) in the derivation cohort and 0.77 (95% CI: 0.76–0.77) in the validation cohort for mortality, similar findings in our study where greater comorbidity measured by Charlson and greater severity by 4 C mortality score were related to greater mortality in patients with COVID-19 [18, 30, 31].