In a previous study, we reported that GCA, a secreted protein from proinflammatory and senescent subtypes of myeloid cells, induces skeletal aging by suppressing bone turnover and promoting marrow fat accumulation.[17] Given the critical role of the proinflammatory secretome in angiogenesis and tissue regeneration, we hypothesized that the myeloid cell‐derived secretory protein‐GCA may be involved in the regulation of wound healing in diabetes. This evidence concerns the gene GCA and diabetes mellitus.