Previous studies indicated that impaired function of the HIF‐1α/VEGF pathway is a central pathogenic mechanism for compromised angiogenesis and delayed wound healing in diabetes.[21, 22, 23, 24, 25, 26, 27] Additionally, ERK activity is the key regulator of the HIF‐1/VEGF pathway in a various of disease condition. The gene discussed is HIF1A; the disease is diabetes mellitus.