Similar to what was observed in the orthotopic pancreatic tumor model, G5‐CHC‐R+US treatment induced higher numbers of matured DCs in lymph nodes (Figure S42, Supporting Information) and more activated CD8+ T cells in the splenocytes (Figure 7c–e; Figure S43a, Supporting Information), indicating the initiation of the robust systemic immune responses. The gene discussed is CD8A; the disease is pancreatic neoplasm.