It is well established that intratumoral hypoxia increases hypoxia‐inducible factor 1 alpha (HIF‐1α) protein levels, which correlates with facilitated tumor growth and metastasis.[29] ROS has been reported to downregulate the activity of HIF‐1α via inhibiting HIF‐1 DNA‐binding activity and accumulation under hypoxia.[30] Immunofluorescence staining of HIF‐1α in tumor sections showed the significant decreased signals in groups treated with G5‐CHC+US and G5‐CHC‐R+US (Figure 3i), suggesting an association with enhanced ROS levels. Here, HIF1A is linked to neoplasm.