NTSR1 and neoplasm: This porphyrinic derivative, named Chenghai chlorin (CHC), showing high sono‐sensitive activity, excellent tumor targetability, and good biocompatibility was chemically modified on G5 surface.[9, 20] Subsequently, the immunomodulator R848 was conjugated with G5 via a hypoxia‐sensitive linker, being cleavable by nitroreductase (NTR) highly expressed in tumor tissues.[21] Due to the ultrasmall size, the nano vaccines G5‐CHC‐R exhibited excellent tumor target and penetration capacities.