Type I IFNs can be induced following recognition of cytosolic DNA/RNA by host pattern recognition receptors (PRRs) like Toll‐like receptors (TLRs), cGAS, and retinoic acid‐inducible gene I (RIG‐I).[33] It is reported that tumor‐derived DNA triggers the production of type I IFNs in CD11c+ tumor‐infiltrating DCs through cGAS‐STING pathway, thus priming the CD8+ anti‐tumor immune response.[34] Our data indicate that the release of cytosolic DNA, including both mtDNA and gDNA triggered by ROS, stimulates the induction of type I IFNs in tumor cells via cGAS‐STING pathway. The gene discussed is CGAS; the disease is neoplasm.