We further revealed that the cytosolic DNA and Mn2+ released by Mn‐N/C coordinately activated the cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING)signaling, consequently stimulating type I interferon (IFN) induction, which was critical for Mn‐N/C‐mediated anti‐tumor immune response. This evidence concerns the gene STING1 and neoplasm.