Type I IFNs elicit the downstream signaling via binding the surface Interferon Alpha Receptor 1 (IFNAR1) to stimulate the transcription of numerous ISGs.[22] To investigate whether type I IFN signaling was critical for Mn‐N/C‐activated immune response, we inoculated MC38‐OVA tumor cells into WT and Ifnar1−/− mice followed by Mn‐N/C or vehicle administration. Here, IFNAR1 is linked to neoplasm.