Similarly, in another transplanted colon cancer model established by ovalbumin (OVA)‐expressing MC38 (MC38‐OVA) tumor cells, the intratumoral administration of Mn‐N/C significantly blunted tumor growth (Figure S3D, Supporting Information), augmented CD8+T cell infiltration (Figure S3E, Supporting Information) and enhanced the cytotoxic function of CD8+ T cells (Figure S3F, Supporting Information). Here, CD8A is linked to malignant colon neoplasm.