NAMPT and colorectal carcinoma: Recently, single‐cell analysis of CRC has revealed that myeloid cells have a high degree of plasticity that is driven by signals within the TME and that the functional phenotypes of TAMs are associated with CRC progression and clinical outcome.[11, 12] The role of NAMPT in TAMs and the TME has not been fully elucidated, particularly with regard to the pathogenesis, progression, and/or prognostic significance of CRC.