SPP1 and neoplasm: While excluding the two resident tissue macrophages, which showed preferential enrichment in normal mucosa versus tumors, we used three blood‐enriched clusters (i.e., CD14+/CD16+ monocytes), a tumor‐enriched FCN1+ monocyte‐like cell cluster, and two tumor‐enriched tumor‐associated macrophage (TAM) clusters (i.e., C1CQ+ and SPP1+TAMs) for further analyses (Figure 1C, left panel).