SPP1 and colorectal carcinoma: This is interesting because SPP1+ macrophages are a unique subset of TAM associated with immunosuppressive activity, and have pro‐tumorigenic/pro‐metastatic roles in CRC.[11, 12] We next divided SPP1+ TAMs into NAMPTlow and NAMPThigh groups based on the median expression of NAMPT (Figure 1E).