Mevalonate metabolism is used in multiple anabolic processes that support cancer cell growth and proliferation especially when cholesterols are abundant.[18] High fat diets (HFD) lead to more cholesterol synthesis and can promote tumor growth in mice models via activating YAP/TAZ pathway.[19] We previously found that AKT can directly phosphorylate CSN6 at S60.[9a] Thus, we employed HA‐AKT, HA‐β‐Catenin, and SB transposon to deliver these constructs into liver of Csn6fl/fl C57 mice by hydrodynamic tail vein injection (HDTI) to establish CSN6 high liver cancer model. Here, COPS6 is linked to liver cancer.