COPS6 and neoplasm: Importantly, Csn6 liver‐specific knockout (Csn6fl/fl; Alb‐Cre (Csn6LKO)) mice attenuated tumor growth after DEN/CCl4 treatment (Figure 1F,G), with significantly decreased liver injury markers including alanine amino transferase (ALT), aspartate amino transferase (AST), and lactate dehydrogenase (LDH) when compared with Csn6fl/fl mice (Figure 1H).