WEE1 and hepatocellular carcinoma: Hepatocellular carcinoma (HCC) is a common liver cancer and is responsible for numerous deaths worldwide.[1, 2] Despite the utilization of conventional systemic cytotoxic chemotherapeutic agents, protein kinase inhibitors, and immunotherapy, HCC continues to pose significant challenges in terms of treatment.[3, 4, 5, 6] Hence, there is a pressing need to explore alternative therapeutic approaches.