After FSP‐RZ‐BPH treatment, TLRs signaling pathway, cGAS‐STING signaling pathway and NF‐κB signaling pathway related genes were significantly up‐regulated compared to the NS group (Figure 6g), and this proved the possible mechanism for R848 and Zn2+ to play a synergistic immune‐promoting effect. Here, CGAS is linked to benign prostatic hyperplasia.