It can modify the immunosuppressive TME by inducing ICD,[35] promoting the polarization of macrophages to M1 phenotype,[36] increasing T cell infiltration, and reducing PD‐L1 expression.[37] Furthermore, delivery of NO using nanocarriers can improve tumor vascular normalization, effectively ameliorate the hypoxic microenvironment of tumor tissues, and enhance anticancer therapy. Here, CD274 is linked to neoplasm.