ACTA1 and melanoma: As shown in Fig. 2A, we generated a triple transgenic mouse strain, α-SMA-CreERT2; Rosa-rtTA; tetO-Yap1, that inducibly overexpresses YAP1 protein in α-SMA+ fibroblasts and determined whether YAP1-overexpressing α-SMA+ fibroblasts could accelerate melanoma progression.