Twenty-one days after tamoxifen injection when mice were sacrificed, YAP1 KO melanomas were significantly smaller in size (Fig. 1D) and lighter in weight (Fig. 1E) (555.91 ± 160.70 mm3, 0.59 ± 0.16 g) than Ct tumors (906.43 ± 205.25 mm3, 1.04 ± 0.20 g), suggesting that D4M melanoma growth was suppressed upon the loss of YAP1 in CAFs. This evidence concerns the gene YAP1 and melanoma.