KLK3 and cancer: Currently, none of the clinicopathological parameters (such as ISUP/Gleason grade, cancer stage, pre-operative PSA), nomograms (such as the MSKCC score, Roach formula, Briganti score, Partin tables), and various imaging tools (MRI, CT scan, PSMA PET/CT, mpMRI) could detect PLNM with high precision.