TRPM2 and familial dilated cardiomyopathy: To explore whether TRPM2 knockdown alleviated DCM injury under diabetic conditions, we knocked down TRPM2 expression with by a single caudal vein injection of ~ 1 × 1011 genome copies of recombinant AAV9-U6-shTRPM2 at 6 weeks of age in the corresponding mice.