INS and diabetes mellitus: Lastly, a TCR responsive to the unmodified insulin B:9–23 epitope was also identified as pathogenic; however, its potency was lower, resulting in diabetes in only 33% of the mice, compared with the 100% incidence for both BDC-2.5 and BDC-10.1, as well as the 71% and 56% observed for NY4.1 and BDC-6.9, respectively.