TOP2A and breast cancer: In this study, hub genes associated with the development of BC were identified and characterised (i.e., KIF2C, NUSAP1, MELK, PBK, KIF20A, AURKA, NCAPG, TPX2, KIF4A, ASPM, AURKB, CDC20, CCNB1, BUB1B, CCNB2, CCNA2, BUB1, TOP2A, UBE2C, TTK, TRIB3, GPM6B, CYP2U1, SNCA, PLP1, LGI4, RELN, MPZ, CDH19, GFRA3, COBL, and SNAP25).