In this study, hub genes associated with the development of BC were identified and characterised (i.e., KIF2C, NUSAP1, MELK, PBK, KIF20A, AURKA, NCAPG, TPX2, KIF4A, ASPM, AURKB, CDC20, CCNB1, BUB1B, CCNB2, CCNA2, BUB1, TOP2A, UBE2C, TTK, TRIB3, GPM6B, CYP2U1, SNCA, PLP1, LGI4, RELN, MPZ, CDH19, GFRA3, COBL, and SNAP25). The gene discussed is PBK; the disease is breast cancer.