In this study, hub genes associated with the development of BC were identified and characterised (i.e., KIF2C, NUSAP1, MELK, PBK, KIF20A, AURKA, NCAPG, TPX2, KIF4A, ASPM, AURKB, CDC20, CCNB1, BUB1B, CCNB2, CCNA2, BUB1, TOP2A, UBE2C, TTK, TRIB3, GPM6B, CYP2U1, SNCA, PLP1, LGI4, RELN, MPZ, CDH19, GFRA3, COBL, and SNAP25). This evidence concerns the gene RELN and breast cancer.