To probe the correlation of expression of 13 MRDEGs (ADAM8, C5AR1, CCL22, CIITA, CTSD, CXCL8, CXCL9, FABP4, MMP3, MS4A1, SPP1, TIMP1, WNT5A) with the incidence of CRC, univariate/multivariate Cox regression analysis was implemented on expression levels of MRDEGs and clinical variables M stage, N stage, and T stage with prognostic clinical relationship in TCGA-COADREAD dataset. The gene discussed is WNT5A; the disease is colorectal carcinoma.