Then we generated ROC curves for 15 MRDEGs (SLC11A1, SPP1, CXCL9, MMP3, CXCL8, CIITA, C5AR1, WNT5A, PDGFRA, FABP4, TIMP1, CCL22, CTSD, ADAM8, MS4A1) in both TCGA-COADREAD and GEO datasets, demonstrating the association between high/low scores of these genes and CRC patients. This evidence concerns the gene SPP1 and colorectal carcinoma.