SPP1 and malignant colon neoplasm: In this study, the expression levels of 15 MRDEGs (SLC11A1, SPP1, CXCL9, MMP3, CXCL8, CIITA, C5AR1, WNT5A, PDGFRA, FABP4, TIMP1, CCL22, CTSD, ADAM8, MS4A1) were analyzed in two groups of colon cancer patients with high/low scores in both TCGA-COADREAD (Fig. 6A) and GEO datasets (Fig. 6B).