To this end, first we treated CML mice in Ls (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${c}_{5}$$\end{document}c5) with TOTO, which resulted in complete suppression of BCR::ABL. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.