As a result of NED, PCa cells show decreased expression of luminal lineage markers such as AR and prostate-specific antigen (PSA) coupled with increased expression of alternative neuroendocrine (NE) lineage markers such as enolase 2 (ENO2), chromogranin A (CHGA) and synaptophysin (SYP)7,9. Here, ENO2 is linked to posterior cortical atrophy.