Concretely, genetically predicted the IgD+ CD38− B cell %lymphocyte demonstrated a nominally causal effect on PD (OR 1.052, 95% CI 1.001–1.106, P = 0.046); the CD20 on IgD− CD24− B cell showed a nominally causal effect on PD (OR 1.060, 95% CI 1.005–1.117, P = 0.032); the CD38 on IgD+ CD24− B cell exhibited a nominally causal effect on PD (OR 1.113, 95% CI 1.028–1.206, P = 0.009); and the BAFF-R on CD20− B cell revealed a nominally causal effect on PD (OR 1.093, 95% CI 1.010–1.184, P = 0.027). Here, TNFRSF13C is linked to Parkinson disease.