A total of five B cell subtypes had a nominally correlation with the development of PD, among which IgD+ CD38− B cell %lymphocyte, CD20 on IgD− CD24− B cell, CD38 on IgD+ CD24− B cell, BAFF-R on CD20− B cell are the causative factors of PD, while CD38 on Plasma Blast-Plasma Cell is protective against PD. This evidence concerns the gene CD38 and Parkinson disease.