Additionally, to elucidate the specific effects of SCZ-linked mutations, we characterized one epilepsy-associated mutation A727T28 in the LBD, and three missense GRIN2A mutations associated with DD/ID in the linker/TMD regions: M653I, S809R, and L812M20,30 the latter of which has previously been characterized22 (Fig. 1A, Fig. S1). Here, GRIN2A is linked to epilepsy.