Infections have been reported with the use of T-cell–redirecting bispecific antibodies; however, infections were reported less frequently in trials of GPRC5D-targeting T-cell–redirecting bispecific antibodies compared with trials of BCMA- and Fc receptor-like protein 5–targeting bispecific antibodies [58–61], which may be due to the more limited expression profile of GPRC5D in the immune compartment compared with the expression profiles of these other target antigens [20, 21, 25–27]. This evidence concerns the gene TNFRSF17 and infection.