The results of our flow cytometry analysis of PD-L1 expression in RNase1-treated HCC cells were in agreement with findings in those previous studies and indicated a mechanism by which RNase1 induces PD-L1 expression by activating the EphA4/ERK pathway in HCC cells (Supplementary Fig. 2j–, l). This evidence concerns the gene RNASE1 and hepatocellular carcinoma.