RNASE1 and neoplasm: Furthermore, we analyzed the population of iNOS+CD206- TAM (M1-like TAM) and iNOS-CD206+ TAM (M2-like TAM) in mice bearing orthotopic HCA-1-Vec and HCA-1-RNase1 tumor, and we found a significantly decreased infiltration of M1-like TAM, whereas an increased infiltration of M2-like TAM in HCA-1-RNase1 tumors, than in HCA-1-Vec tumors (Fig. 2n–p).