Taken together, the positive correlations among RNase1 expression, CD206+ TAM infiltration, and PD-L1 expression and negative correlation between RNase1 expression and CD8+ T-cell infiltration in tumor sections (representative cases shown in Fig. 7d) supported that RNase1 is a potential biomarker for predicting immunosuppressive TMEs in HCC patients. This evidence concerns the gene CD8A and hepatocellular carcinoma.