Therefore, we further compared the populations of short-lived effector and memory precursor effector cells in each group of mice described above and found more memory precursor effector cells isolated from rechallenged mice than from tumor-free and tumor-bearing control mice, suggesting that combination therapy with an ALKi and αPD-1 can give rise to long-lived CD4+ and CD8+ Tmem cells (Fig. 6j,, k, Supplementary Fig. 6f,, g). The gene discussed is CD8A; the disease is neoplasm.