In conjunction with our previous experiments where we show that inhibition of GZMB alone does not impair killing of NALM6 tumor cells, here we show combined blockade of the Fas pathway and GZMB inhibition does not impair killing of NALM6 tumor cells, suggesting the importance of alternate cytotoxic mechanisms that can be responsible for CAR T cell-mediated cytotoxicity. The gene discussed is FAS; the disease is neoplasm.