Nielsen and colleagues found that in patients with coronary artery disease, left ventricular mtp mRNA levels were negatively correlated with tissue triglyceride content, and it was hypothesized that upregulation of transcripts of mtp (and possibly apoB) in the ventricle could contribute to the reduction of triglyceride accumulation in hypoxic hearts (Bjorkegren et al., 2001). This evidence concerns the gene APOB and coronary artery disorder.