HMOX1 and malaria: In support of the latter, there are “additional” HMOX1 gene variants enhancing HO-1 expression that were associated with reduced susceptibility to P. falciparum CM in children (Sambo et al, 2010), consistent with experimental models of malaria in mice (Pamplona et al, 2007; Ferreira et al, 2008; Jeney et al, 2014).