This suggests that, in contrast to other components of the heme/iron detoxifying pathway, including HO-1 (Pamplona et al, 2007; Ferreira et al, 2008; Seixas et al, 2009; Jeney et al, 2014; Ramos et al, 2019, 2022; Wu et al, 2023), ferritin H chain (Gozzelino et al, 2012; Ramos et al, 2019) or ferroportin 1 (Zhang et al, 2018; Wu et al, 2023), HP and HPX are not essential to survive malaria in adult mice. The gene discussed is HMOX1; the disease is malaria.