HPX and infection: The virulence of other rodent-infective Plasmodium strains was also similar in adult Hp−/−Hpx−/− versus age-matched control Hp+/+Hpx+/+ mice, as assessed for P. berghei ANKA (Fig 4B) or P. berghei NK65 infection, with the latter failing to elicit experimental CM in Hp−/−Hpx−/− mice (Fig 4C).