SERPINB3 and metabolic dysfunction-associated steatohepatitis: To mechanistically investigate the role of SerpinB3 in relation to the development of murine NASH, we took advantage of mice genetically manipulated to carry a deletion in the reactive site loop of Serpinb3a [38], the closest isoform to human SerpinB3, hereafter indicated as knock-out (KO) mice, as well as their related wild-type (WT) mice on the common genetic background BALB/c.