Our analyses using bioinformatics, online software prediction, and genetic pattern analysis, we concluded that variant c.3245A>G (p.His1082Arg) of the AMER1 gene, which is associated with X-chromosome recessive inheritance, and c.238G>C (p.Val80Leu) of the KCNE1 gene, which is inherited in an autosomal accessory manner, may cause the CHD in this family line. The gene discussed is KCNE1; the disease is coronary artery disorder.