Notably, clinical data surveys have revealed that 20% to 30% of depressed patients experience circadian rhythm disorders.[6] Sleep disorder represents one of the most prominent clinical manifestations of circadian rhythm disruptions in depressed individuals, with up to 90% of patients exhibiting varying degrees of sleep-related symptoms.[7] By regulating the expression of circadian clock genes, the improvement of circadian disorders has emerged as a significant target for depression intervention. Here, CLOCK is linked to major depressive disorder.