ADAM33 and asthma: These symptoms can cause wheezing, coughing, chest tightness, and shortness of breath.[1,2] According to recent studies, asthma is caused by a combination of Th1 (aiding in eliminating the pathogen but involving in airway inflammation), Th2 (causing bronchoconstriction), and Th17 (inducing asthma airway remodeling) immunologic mechanisms and genetic predisposition (related gene: ADAM33, PHF11, DPP10, GPRA, and SPINK5).[3]