CCL2 and neoplasm: Inflammatory mediators are a group of cytokines that are generated during the inflammatory response, such as E-selectin, monocyte chemotactic protein-1, tissue factor, interleukin 6 receptor, and fatty acid binding protein 4.[55–57] The heightened expression of these inflammatory mediators has been closely associated with various facets of tumor initiation, growth, angiogenesis, metastasis, and resistance to chemotherapy.