IDH wild-type glioma frequently exists other molecular alterations, such as epidermal growth factor receptor amplification and telomerase reverse transcriptase promoter mutation, which makes them much more similar to glioblastoma.[11] The BTG patients ranged in age from 3 months to 80 years.[12,13] There is a wide spectrum of clinical presentations in patients with AA including focal neurological deficits, headache, speech disorders, dementia, gait disturbances, seizures, which correspond to the location of the tumor. This evidence concerns the gene EGFR and central nervous system cancer.