NFKB1 and hypertensive disorder: It can be used to treat inflammation, hypertension, tumors and other diseases.[67,68] The researchers found that Cyn could alleviate joint swelling and M1 macrophage infiltration in GA mice.[69] After treatment with Cyn, the expression of inflammatory factors and NF-κB-related proteins in MSU-induced GA mice decreased.[69] In other words, Cyn can inhibit the inflammatory response induced by MSU through the NF-κB signaling pathway, improve inflammatory infiltration of the joint synovium, and protect the joints.