TNF and neoplasm: It has various pharmacological effects, such as inhibition of inflammatory response, antioxidation, and anti-tumor.[79–81] IL-1β is a key cytokine in GA inflammation and is precisely regulated by the NF-κB and NLRP3 inflammasomes.[82] Related experiments have shown that paeonol can inhibit the production of IL-1β in arthritic rats.[83] Administration of paeonol to GA rats for seven consecutive days significantly reduced the expression of TNF-α, IL-1β, and IL-6 in the synovial tissue of rats.