NFKB1 and neoplasm: Icariin (ICA) is the main active ingredient in shorthorned epimedium herbs.[28] It has pharmacological effects such as anti-inflammatory, anti-tumor, anti-oxidative stress and anti-tumor effects.[29–32] In an experiment conducted by Cao,[33] he found that ICA could reduce the swelling rate of ankle joints in GA rats, the expression of inflammatory factors in synovial tissue, and inhibit the nuclear translocation of NF-κB pathway-related proteins.