Previous studies demonstrated that SAL B reduces the levels of serum cTnI, CK-MB, and MDA and increases the levels of serum NO and SOD in the ischemia-reperfusion rat model, so it affects anti-ischemia-reperfusion myocardial injury.[93] During in vitro experiments, SAL B reduced the adhesion of ADP-activated platelets to EA.Hy926 cells inhibited the activation of NF-kB and reduced the protein and mRNA levels of pro-inflammatory factors IC AM-1, IL-1P, IL-6, IL-8, and MCP-1, showing an anti-AS effect[94] (Fig. 1D). The gene discussed is CCL2; the disease is ischemia.