This pathway has been implicated in chronic intermittent hypoxia settings, such as in obstructive sleep apnea, a chronic condition leading to intermittent hypoxia and subsequent activation of the renin-angiotensin-aldosterone system.30 Thus, this gene expression pattern suggests a nonacute nature of intrapartum hypoxia ischemia in South Asia. The gene discussed is REN; the disease is obstructive sleep apnea syndrome.