GRPR and neoplasm: With both Tle10 and NMe-His12 substitutions, the top candidate [68Ga]Ga-LW01110 has higher in vivo stability, tumor uptake and tumor-to-background uptake ratios than clinically validated [68Ga]Ga-RM2 and [68Ga]Ga-AMBA, and is promising for use for detecting GRPR-expressing tumors with PET.