We hypothesized that these genes might be relevant to the systemic effects of hyperglycemia, and in particular, four genes were upregulated across many cell types and organs in STZ mice: the proteoglycan decorin (Dcn), gelsolin (Gsn), matrix Gla protein (Mgp), and metallothionein 1 (Mt1). The gene discussed is DCN; the disease is Hyperglycemia.