Ji and colleagues, for instance, reported that EGFR directly interacts with CK2 in cancer cell lines, resulting in enhanced CK2 activity and α-catenin phosphorylation (Ji et al., 2009), whereas a study from our laboratory showed that pharmacological EGFR-inhibition of aNS by AG-1478 initiates nuclear accumulation of MEIS2 and neuronal differentiation even under culture conditions that otherwise keep cells in an undifferentiated cellular state (Kolb et al., 2018). This evidence concerns the gene EGFR and cancer.