Consistent with these phenotypes, heterozygous MEIS2 missense mutations or 15q14 microdeletion involving the MEIS2 gene locus are characterized by a triad of cleft palate, atrial or ventricular septal heart defects, and intellectual disability, known as MEIS2 syndrome (Verheije et al., 2019). Here, MEIS2 is linked to Intellectual disability.