MEIS2 and cancer: Ji and colleagues, for instance, reported that EGFR directly interacts with CK2 in cancer cell lines, resulting in enhanced CK2 activity and α-catenin phosphorylation (Ji et al., 2009), whereas a study from our laboratory showed that pharmacological EGFR-inhibition of aNS by AG-1478 initiates nuclear accumulation of MEIS2 and neuronal differentiation even under culture conditions that otherwise keep cells in an undifferentiated cellular state (Kolb et al., 2018).