Leucine-rich repeat protein kinase 2 (LRRK2), or dardarin, is a large multi-domain cytoplasmic protein mainly expressed in brain, lungs, macrophages, and kidney [1], and mutations in LRRK2 are one of the major causes of inherited and sporadic Parkinson's disease (PD). The gene discussed is LRRK2; the disease is Parkinson disease.