In HCC, lysine-specific demethylase 1A (LSD1), the first identified histone-specific demethylase, has been found to enhance the immunosuppressive activity of HCC by promoting PD-L1 abundance and reducing the methylation of myocyte enhancer factor 2D (MEF2D) [155]. The gene discussed is KDM1A; the disease is hepatocellular carcinoma.