CHI3L1 and Hepatic fibrosis: A meta-analysis showed that serum CHI3L1 served as an excellent marker to diagnose liver fibrosis, in which the pooled diagnostic values were significantly higher than the clinical indicators such as FibroScan, the aspartate aminotransferase-to-platelet ratio index (APRI), and the fibrosis-4 (FIB-4) index [9].