Plumbagin (PLB; 5-hydroxy-2-methyl-1,4-naphthoquinone) inhibits GBM growth in vitro and in vivo through ferroptosis mediated by targeting NAD(P)H quinone dehydrogenase 1 (NQO1) and GPX4 (69). The gene discussed is GPX4; the disease is glioblastoma.