For example, Shikonin, a natural naphthoquinone isolated from the roots of Lithospermum erythrorhizon, can induce apoptosis and necrotic of GBM cells (35) by inhibiting EGFR phosphorylation and decreasing phosphorylation of EGFR downstream molecules, including AKT, P44/42MAPK and PLCγ1. Here, AKT1 is linked to glioblastoma.