According to the statistical analysis for expression data of in-house tissue microarray, ZIC2 expression was significantly higher in 159 oral cancer tissues compared with that in 48 noncancer oral tissues (7.89 ± 1.994; 1.46 ± 1.868, P < 0.05) (Figure 1(g)). Here, ZIC2 is linked to lip and oral cavity carcinoma.