The study of Le Magnen et al. reported the cytoplasmic location of transcription factor Klf4 with in prostate cancer, and it was related to an oncogenic differentially spliced isoforms of Klf4 without nuclear localization signal encoded in exon three [19], which might also explain the mainly cytoplasmic staining of ZIC2 in the present study. Here, KLF4 is linked to Familial prostate cancer.