While oral cancer patients with lower expression of ZIC2 have improved survival probability than oral cancer patients with higher expression of ZIC2 in TCGA dataset (P = 0.011), the overexpression of ZIC2 in GSE85446 indicated worse overall survival of oral cancer patients (P < 0.001) (Figures 8(a)–8(d)). Here, ZIC2 is linked to lip and oral cavity carcinoma.