SERPINE1 and acute kidney injury: Prior work emphasizing a deleterious role for PAI-1 in AKI showed that young mice lacking PAI-1 have increased survival, improved kidney function, decreased apoptosis, reduced inflammation, attenuated fibrin deposition in the kidneys, and increased levels of circulating activated protein C as compared to WT mice after LPS challenge (Gupta et al., 2015; Nakayama et al., 2023).