In contrast, we observed a trend toward increased C3a (54,085 ± 7,017 ng/ml; p=0.07) but not C5a (46.5 ± 10.5 ng/ml) serum levels increased in FD patients with nonsense mutations as compared to those with missense mutations (C3a: 29,126 ± 10,245 ng/ml; C5a: 35.1 ± 7.8 ng/ml) (Figures 2B, C, G, F). The gene discussed is C3; the disease is Fabry disease.