CD8A and neoplasm: The expression of GSDME enhances the absorptive abilities of TAMs and amplifies the count and effectiveness of tumor-infiltrating NK cells and CD8+ T cells, along with the expression of key molecules (GZMB, IFN-γ, and TNF-α) in tumor-infiltrating lymphocytes (TILs), potentially bolstering antitumor adaptive defenses (84, 85).