Researchers have produced dichloroacetate polymer micelles (OPDEA-PDCA) that can induce mitochondrial oxidative stress by inhibiting pyruvate dehydrogenase kinase 1 (PDHK1), leading to GSDMD-mediated pyroptosis of osteosarcoma cells and enhancing osteosarcoma immunotherapy (125). Here, GSDMD is linked to osteosarcoma.