Nrf2 protein levels in serum and renal tissues were significantly higher in patients with LN than in healthy controls in the absence of decreases in eGFR, when patients may be in a state of high oxidative stress, triggering Nrf2 accumulation with adjacent translocation to the nucleus and induction of antioxidant target genes, thereby activating the Nrf2 system to counteract oxidative stress (34). Here, NFE2L2 is linked to lobular neoplasia.