In conclusion, our study found that Nrf2 protein levels were significantly higher in patients with LN when they displayed a normal glomerular filtration rate (eGFR ≥90 ml/min/m2) than when they had reduced glomerular filtration rates (eGFR <90 ml/min/m2) and decreased when LN was in remission. This evidence concerns the gene NFE2L2 and lobular neoplasia.