There are some genes that have very log fold change values between patients with early-stage colorectal cancer and patients with metastatic colorectal cancer such as TRIM3, ABCB1, FOXA1, GRM8, LEFTY1, LYZ, HUNK, IFIT1, LY6G6D, MX1, RETNLB, RSAD2, SRFP2, and WIF1. The gene discussed is GRM8; the disease is colorectal cancer.