There are some genes that have very log fold change values between patients with early-stage colorectal cancer and patients with metastatic colorectal cancer such as TRIM3, ABCB1, FOXA1, GRM8, LEFTY1, LYZ, HUNK, IFIT1, LY6G6D, MX1, RETNLB, RSAD2, SRFP2, and WIF1. This evidence concerns the gene WIF1 and metastatic colorectal cancer.